Global case of the month

Above are photos of a lady with reduced vision and irritation on her right eye.

Questions:

1) What is the diagnosis?

2) With simple excision what is the risk of recurrence?

Answers:
1. Pterygium

2. Very high especially in young patients, maybe 70 to 80 %

Discussion:
Pterygium, literally wing, rarely causes visual disturbance in patients seen in the UK but in hot dusty environments pterygia may be very advanced and cross the pupil margin. 

In this case the lesion looks typical but occasionally a squamous cell neoplasm may be mistaken for a pterygium.  

After excision, techniques to reduce the risk of recurrence include application of agents such as mitomycin to suppress fibroblast regrowth or use of a conjunctival autograft to replace limbal stem cells.

Corneal pterygium  >2mm into the cornea, invasion of granulation tissue, stocker's (iron) line, involving epithelium and bowman's. Pain = infiltration of corneal nerves

Indications for Surgery

1) Visually significant induced astigmatism

2) Threat of involvement of the visual axis

3) Severe symptoms of irritation

Examples of surgical techniques include:

Bare sclera, simple closure, flap, rotational conj flap

Adjuncts to reduce the risk of recurrence include:

MMC, 5 FU, cyclosporin A, Bevacizumab, beta radiation, Amniotic membrane

 

Surgical excision and graft

Aim to achieve a smooth corneal surface and low recurrence.

Excision of the pterygium - dissect a smooth plane from the cornea towards limbus, down to sclera but leaving episcleral vessels intact.

Conjunctival autograft technique - Recurrence rates ~2- 40%. Autograft obtained from the supero(temporal) bulbar conjunctiva, and removal of Tenon's tissue. It is then sutured to cover the exposed sclera. MMC (inhibit fibroblasts) can be used directly to the scleral bed after pterygium excision as an adjunct to reduce recurrence. Healing may take 6 weeks +

Complications include: graft failure, granuloma, scarring, infection, delayed healing, diplopia, perforation, and recurrence (to name a few).